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This miniature infusion pump is designed for precise and continuous long-term dosing in mice and rats, durations for up to 6 weeks, which relieves researchers who are burdened by multiple injections.
It can be implanted subcutaneously or intraperitoneal for systemic administration, or connected to a catheter to provide targeted delivery for blood vessels, brain, spinal cord, or other specific areas infusion.
The osmotic pump consists of a robust semi-permeable membrane that allows animals’ fluids to pass through. Built-in high-pressure salt interlayer, which absorbs animal fluids, causing them to expand and squeeze the drug storage capsule. The stored liquid in the capsule can be delivered to specific tissue area continuously and accurately at a constant rate.
Osmotic Pumps consist of three concentric layers: the inner drug reservoir the osmotic layer, and the outer. When the
pump is implanted water is absorbed through the outer membrane. The water entering the pump expands the osmotic layer,
which compresses the flexible, impermeable reservoir.
Applications
- Cardiovascular disease model
- Addiction Research
- Emotion-based research
- Medication research for diabetes and other metabolic diseases
- Pain, injury, and other therapeutic drug infusions
- Cancer Drug Screening
Positions of the implanted pump and the drug pumped out
The pump can be implanted directly into the peritoneal cavity or the back of the neck to deliver the drug.
Drug delivery can be even for specific tissues, such as vessels, inner brain, spinal cord, lung, liver etc., just by attaching catheters or other accessories.
Size of Pump
3 sizes models: 100ul, 200ul, and 2ml. The pump rate is stable through in-vivo testing.
Benefits of material
Made by biocompatible material to avoid immune rejection after implantation in rats and mice. Each pump is also sterilized by irradiation to ensure no inflammatory reaction in mice and rats.
Advantages
Stable Pumping Rate
Predictable dosing and minimizes experimental variables to ensure reproducible and consistent results.
Reduced Stress Response to Mice and Rats
Different from the traditional multiple injections, it reduces the stress response by continuous administration, without frequent animal handling, that ensures the experimental results and that animal welfare is guaranteed.
Wide Application, Easy to Operate
Reducing the need for regular injections at night and on weekends. It can be directly subcutaneously or intraperitoneally embedded for systemic drug delivery, or connected to a catheter for use in other specific tissues or organs such as blood vessels, brain, liver, etc.
Specifications
| Capsule | 100μl | 200μl | 2mL | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Type | 1003D | 1001W | 1002W | 1004W | 2003D | 2001W | 2002W | 2004W | 2mL1W | 2mL2W | 2mL4W |
| Duration | 3D | 1W | 2W | 4W | 3D | 1W | 2W | 4W | 1W | 2W | 4W |
| Pumping Rate(μL/hr) | 1 | 0.5 | 0.25 | 0.125 | 2 | 1 | 0.5 | 0.25 | 10 | 5 | 2.5 |
| Cap | Without | PE material | |||||||||
| Flow regulator | 304 stainless steel material | ||||||||||
| Infusion tube | Flat head for the injection of liquid | ||||||||||
| Models | Description | Content |
|---|---|---|
| 1003D | 100μl Standard Kit, 1 μL/hr for 3 days |
|
| 1001W | 100μl Standard Kit, 0.5 μL/hr for 1 week | |
| 1002W | 100μl Standard Kit, 0.25 μL/hr for 2 weeks | |
| 1004W | 100μl Standard Kit, 0.125 μL/hr for 4 weeks | |
| 2003D | 200μl Standard Kit, 2 μL/hr for 3 days | |
| 2001W | 200μl Standard Kit, 1 μL/hr for 1 week | |
| 2002W | 200μl Standard Kit, 0.5 μL/hr for 2 weeks | |
| 2004W | 200μl Standard Kit, 0.25 μL/hr for 4 weeks | |
| 2mL1W | 2ml Standard Kit, 10 μL/hr for 1 week | |
| 2mL2W | 2ml Standard Kit, 5 μL/hr for 2 weeks | |
| 2mL4W | 2ml Standard Kit, 2.5 μL/hr for 4 weeks |
| Models | Description | Content |
|---|---|---|
| Bic-3 | Optional kit for 1-3mm deep brain area administration (10 Bags/ Package) |
|
| Bic-5 | Optional kit for 3-5mm deep brain area administration (10 Bags/ Package) | |
| Bic-X | Optional kit customized length 1-9mm (in 0.1mm increments), for 1-9mm deep brain area administration (10 Bags/ Package) |