Najate Achamrah, Séverine Nobis, Jonathan Breton, Pierre Jésus, Liliana Belmonte, Brigitte Maurer, Romain Legrand, Christine Bôle-Feysot, Jean Luc do Rego, Alexis Goichon, Jean Claude do Rego, Pierre Déchelotte, Sergueï O Fetissov, Sophie Claeyssens & Moï

A role of gut-brain axis emerges in the pathophysiology of anorexia nervosa and maintaining adapted physical activity during refeeding remains discussed. We aimed to assess gastrointestinal protein metabolism and investigate the contribution of physical activity during refeeding in C57BL/6 mice with activity-based anorexia (ABA). ABA mice exhibited lower body weight and food intake with increase of lean mass/fat mass ratio and fat oxidation. Colonic permeability was increased in ABA. Ad libitum food access was then restored and ABA group was divided into two subgroups, with access to running wheel (ABA-PA) or not (ABA-NPA). After refeeding, fat free mass was completely restored only in ABA-PA. Colonic permeability was enhanced in ABA-NPA. Finally, muscle kynurenine conversion into kynurenic acid was lower in ABA-NPA who also exhibited altered behavior. Maintaining physical activity during refeeding may thus limit colonic hyperpermeability and improve behavior in anorectic mice.

Date de parution
Scientific Reports 6, Article number: 21887