Nous sommes heureux d'annoncer notre participation au 49ème Colloque de l’AFSTAL, “Des animaux et des machines” qui se tiendra du 19 au 21 novembre 2025 à Nantes. Venez nous rencontrer sur notre stand 81.
Actualités
Early stage of metabolic dysfunction associated steatotic liver disease disrupts circadian rhythm and induces neuroinflammation in rats
Abstract
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a chronic liver disease affecting 25% of the European population, with rising global incidence. Liver damage includes ballooning, steatosis, inflammation and fibrosis. Associated brain disorders include sleep, cognitive issues, anxiety, and depression. While neurological complications in advanced MASLD are well documented, early cerebral…
Sex-dependent effects of intestinal epithelial TLR4 deletion induced before activity-based anorexia
Rationale A role for the microbiota-gut-brain axis in the pathophysiology of anorexia nervosa (AN) has emerged in the last decade. An alteration of intestinal Toll-like receptor type 4 (TLR4) has been reported in the activity-based anorexia (ABA) model with an increase in its expression at the cell surface of colonic epithelial cells. In addition, inducible TLR4 invalidation in intestinal epithelial cells (IECs) was associated with behavioral and…
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