Activity wheel and software

The activity wheel and software is ideal for measuring the free and spontaneous activity of mice or rat in their home cage. 

Intellibio developed a cage equipped with an activity wheel and an electronic unit for recording the measured parameters in Excel (recording of spontaneous motor activity over long periods even over an entire lifetime ).The cage is designed to facilitate the well-being of animals and meet the research needs.

set of mouse wheel activity
set of mouse wheel activity
Roues Activi-Wheel modèle rat et souris

Scientific interests

The device adapts to a standard cage for rat and mouse. Thus,  the rodent remains in its living area and has free access to the wheel. The equipment measures activity parameters (activity type, time, speed, sense of rotation etc.) in the long-term, even over the entire lifespan of the animal. This cage is designed to facilitate animal welfare.These sets of cages allow the measurement of activity variations and their timing over extended periods, making the system particularly useful for:

  • The study of rhythms of activity and their deregulation
  • Ageing studies
  • Pharmacology (measurements before and after treatment), anxiety and depression
  • Temporal screening in all developmental models (environments pre- and post-natal, KO inducible, injuries ...)
  • Anxiety and depression

 

Software

  • Visualization of the average activity on each wheel.
  • Registration of all wheels on a selected duration.
  • Recording the activity at regular intervals (configurable).
  • Detailed summary by animal activity sequence in the wheel.
  • System requirements 1GHz and 256MB of memory

Software: Accurate measurements and many parameters according to environmental factors and /or chemical records:

  • Spontaneous activity / Rythm of rodent activity (number of laps)
  • Acceleration
  • Direction of rotation (direction)
  • Distance traveled
  • Speed
  • Results include:  a data file computed per period with informations of speed, acceleration, wheel rotations…
  •  Outputs: via txt file in Microsoft Excel format.
  • Features
  • Models
  • Cage rat(s) or mice
  • Transparent polycarbonate (perfect visibility of the rodents)
  • Lid with stainless steel wire safety clip on the cage, bottle location and pellets
  • Stainless steel wheel and low friction for a very gentle motion
  • Diameter of the wheel 330 mm (rat), 230 mm (mouse)
  • Precision of the wheel: ± 30°
  • Power: 15 V standard
  • USB connexion
  • Up to 32 Activiwheel

 

  • OPTIONAL:  Wheel locking system controlled by software (block a wheel, a group of wheels or all the wheels) during a period of time.
              ITEM                Description    Dimensions cage mm  Floor area  cm²    ø wheel mm
1301     ActiviWheel  for mice                 365 x 207 x 140  530 230
1302     ActiviWheel for rat  425 x 266 x 185  800 330
1303 ActiviWheel  for several rats   480 x 375 x 210 1500 330

Publications

Dongryeol Ryu, Laurent Mouchiroud, Pénélope A Andreux, Elena Katsyuba, Norman Moullan, Amandine A Nicolet-dit-Félix, Evan G Williams, Pooja Jha, Giuseppe Lo Sasso, Damien Huzard, Patrick Aebischer, Carmen Sandi, Chris Rinsch & Johan Auwerx
Nature Medicine (2016)
Najate Achamrah, Séverine Nobis, Jonathan Breton, Pierre Jésus, Liliana Belmonte, Brigitte Maurer, Romain Legrand, Christine Bôle-Feysot, Jean Luc do Rego, Alexis Goichon, Jean Claude do Rego, Pierre Déchelotte, Sergueï O Fetissov, Sophie Claeyssens & Moï
Scientific Reports 6, Article number: 21887
Mathieu Méquinion, Emilie Caron, Sarah Zgheib, Alicia Stievenard, Philippe Zizzari, Virginie Tolle, Bernard Cortet, Stéphanie Lucas, Vincent Prevot, Christophe Chauveau, Odile Viltart
American Journal of Physiology - Endocrinology and Metabolism
Tatiana Zyryanova, Rick Schneider, Volker Adams, Doreen Sittig, Christiane Kerner, Claudia Gebhardt, Henrik Ruffert, Stefan Glasmacher, Pierre Hepp, Karla Punkt, Jochen Neuhaus, Jörg Hamann, Gabriela Aust
PLOS ONE, Research Article
Sarah Dubreucq, Muriel Koehl, Djoher N. Abrous, Giovanni Marsicano, Francis Chaouloff
Experimental Neurology